UC-II® Undenatured Type II Collagen in feed supplements: Innovation for healthy joints

Joint problems are a growing concern for many pet owners, particularly as their animals age or live highly active lifestyles. Whether it’s a senior dog struggling to climb the stairs or a sporting horse in need of daily joint protection, demand is rising for joint supplements that truly deliver results.

At Nutriliq, we work closely with our partners to develop private label feed supplements that are rooted in science and tailored to market demand. One of the most powerful ingredients we recommend for long-term joint health is UC-II® undenatured type II collagen, a premium, low-dose ingredient with a truly unique mechanism of action.

What makes UC-II® unique?

UC-II® (also known as C-II®) is a patented form of undenatured type II collagen. What makes it stand out from traditional hydrolyzed collagen is that its triple-helix structure remains intact, allowing it to deliver bioactive epitopesthat stimulate a natural immune response in the body – a process known as oral tolerance.

Unique mechanism of action: Activate the body’s own repair process

Unlike common joint ingredients that work by simply reducing inflammation or lubricating joints, UC-II® takes a different approach:

Bind – The intact collagen reaches the Peyer’s patches in the small intestine, where its epitopes bind to immune cells.
Trigger – This interaction stimulates regulatory T cells (Tregs) that modulate the immune response.
Build – These Tregs migrate to the joints and release anti-inflammatory cytokines (like IL-10 and TGF-β), which stimulate chondrocytes to protect and rebuild cartilage.

This mechanism offers long-term benefits and works synergistically with the body’s own processes – something not seen with other collagen types.

UC-II® research: proven effectiveness in animals

Several studies have confirmed the benefits of UC-II® in companion animals:

Improves mobility and joint comfort in dogs with osteoarthritis (OA)
Reduces cartilage degradation in healthy, active dogs
Promotes cartilage regeneration in both dogs and horses

And best of all? These effects are achieved with just 40 mg per day, making UC-II® both effective and highly formulation-friendly.

Why brands choose UC-II® in their formulations

UC-II® is the ingredient of choice for companies seeking:

Efficacy at a low dose
Scientific validation
Easy incorporation in chews, powders, or tablets
Improved compliance through palatable formulations

With osteoarthritis progressing in clear stages – from subtle signs to chronic pain – supporting joint health early can make all the difference. UC-II® is suitable for a wide range of animals and can help delay or reduce the severity of joint problems when used preventively.

Partner with Nutriliq for custom joint support formulas

At Nutriliq, we specialize in private label feed supplements for pets, offering flexibility in both ingredients and delivery formats. Whether you’re targeting aging pets, working dogs, or active breeds, our R&D team is here to co-create a product that fits your brand vision and market goals.

Ready to launch a joint support supplement that truly makes a difference?
Let’s build it together – with UC-II® at the heart of your formulation.

Contact us today to discuss your private label project.

Nutriliq is specialised in development and production of feed supplements for all animal species.

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