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- info@nutriliq.eu
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Healthy joints are essential for the quality of life of pets. This presents an opportunity for manufacturers, veterinarians, and distributors to offer products that truly make a difference. UC-II collagen for pets is one such ingredient: scientifically proven, effective, and perfectly usable in modern formulations.
UC-II® is an undenatured type II collagen that activates the animal’s natural immune response to support joints. Unlike hydrolyzed or denatured collagen, UC-II® retains its 3D structure. This allows the immune system to recognize and utilize it through a process called oral tolerance.
UC-II® works differently than traditional building block supplements like glucosamine and chondroitin. The intact collagen activates the immune system in the intestines through oral tolerance, stimulating anti-inflammatory T cells. These help reduce inflammation and support cartilage repair. In this way, the body actively contributes to protecting its joints.
UC-II® has been shown in several animal studies to be more effective than the classic combination of glucosamine and chondroitin. In dogs and horses with osteoarthritis, up to 88% less pain was observed, with a significant increase in mobility. Even in healthy, active dogs, UC-II® led to improved performance and lower inflammation levels. This makes it a premium ingredient for both preventive and therapeutic applications.
UC-II® has been extensively studied in dogs, cats and horses:
Dogs: less pain, more mobility.
Cats: high palatability and excellent absorption.
Horses: Significant improvement in joint comfort compared to traditional means.
With over two decades of research, UC-II® is one of the best-documented joint health ingredients in the pet industry.
Just 40 mg per day is enough to support the joints of dogs and cats. This means smaller tablets or treats, lower costs, and higher compliance – ideal for brands that want to combine ease of use and effectiveness.
UC-II® is exceptionally flexible in its use in various formulations. Thanks to its heat- and digestion-resistant structure, it maintains its effectiveness in, among other things:
Soft chews: Very suitable because of good stability and high compliance in animals.
Powders: Easy to add to wet food or dose directly.
Liquids: Possible with modified formulation; requires attention to pH and preservatives.
Gummies: Popular in the human sector, emerging in the pet segment.
Tablets & chunks: Proven stable and effective for long-term use in feed.
The graph below illustrates the applicability of UC-II® per formulation based on three criteria: stability, compliance, and ease of formulation.
UC-II® is stable and processable in various applications, such as chews, tablets, and complete pet food. Its heat-resistant structure makes it suitable for processing without loss of effectiveness.
The trend toward pet humanization is driving a growing demand for scientifically proven supplements. Pet owners are seeking reliable solutions, veterinarians are demanding clinically proven ingredients, and distributors are looking for brands with credible claims. UC-II® offers all these benefits in a single ingredient.
For pet supplement brands, this means: lower dosages, greater effect and stronger differentiation in a competitive market.
What is UC-II collageen?
An undenatured type II collagen that activates the immune system through oral tolerance to support joints.
How is UC-II different from glucosamine and chondroitin?
UC-II works immunologically, not as a building block. This makes it more effective at a much lower dose.
Is UC-II safe for long-term use in dogs and cats?
Yes, all studies show that UC-II® is well tolerated, even with long-term administration.
Are you a manufacturer or supplier interested in incorporating UC-II® into your product range? Contact us at info@nutriliq.eu or schedule an online consultation.
